Opzelura is a brand name for the medication ruxolitinib cream 1.5%. It is a topical medication used to treat certain skin conditions. It is a Janus kinase (JAK) inhibitor, which works by blocking the activity of certain enzymes that contribute to inflammation. Opzelura Uses Opzelura is used to treat: Atopic dermatitis (eczema) in adults and children 12 years and older.   Non-segmental vitiligo in adults and children 12 years and older. Benefits Opzelura can help to: Reduce inflammation and itching associated with atopic dermatitis.   Improve skin repigmentation in people with non-segmental vitiligo. Important information Opzelura is a prescription medication that is only available from a healthcare provider. Opzelura can cause serious side effects, including: Serious infections   Major cardiovascular events   Thrombosis   Cancer